The Story Mode follows Makunouchi Ippo's journey from his spar with Miyata Ichirō to his second match against Sendō Takeshi for the JBC featherweight belt. It skips some of his fights from the series such as Oda Yūsuke, Fujiwara Yoshio, Jason Ozuma, Kobashi Kenta, and Ponchai Chuwatana. It also has Ippo fighting Shigeta Akira after losing to Date Eiji instead of fighting Ponchai.
